Endocrine Abstracts

Many surveys have shown that children are ubiquitously exposed to endocrine disruptors (EDs) like bisphenol A (BPA) and phthalates, and many laboratory studies have shown these EDs have adverse effects related to hormone secretion, while the evidence on infants’ mini-puberty has not been observed yet. A prospective cohort was recruited at the early maternal pregnancy stage by the Maternal and Child Health and Family Planning Service Center, Daishan, China, from March 2012...

The placenta is a highly specialized organ, which ensures nutrient uptake, waste elimination, provides thermo-regulation, prevents passage of some xenobiotic molecules and regulates the quantity of thyroid hormones (TH) necessary for the fetal development. It is known, that even minor changes in maternal TH levels, can alter the fetal growth. Several factors can modify TH levels during pregnancy. Among them, increasing evidences show that prenatal exposure to persistent organi...

Thyroid hormones (TH) of maternal origin are critical for the proper fetal development, especially during early pregnancy. Even minor changes in maternal TH circulation can lead to various adverse outcomes. Recent studies found that the metabolites of thyroxine (T4) also play an important physiological role. For example, 3,5-diiodo-L-thyronine (T2) and 3,3′-diiodo-L-thyronine (rT2) can suppress the thyroid stimulating hormone (TSH) level ...